In the fall of 1954, St. Anthony School was established on the site of the O’Brien farm. Louis Bondi was the founding principal and the only staff member of 4 to have teaching experience. In 1982, St. Mary School was twinned with St. Anthony. In 1995, the newest addition included a new library, intermediate division classrooms and senior kindergarten classrooms and a new office.

In 1999, the Niagara Catholic District School Board purchased the land adjacent to the school on the west side. The house and garage were demolished to build a parking lot. A new school sign was elevated in September 2003.

Total enrolment as of September 2009: 544